Avalanche^®-in vivo Transfection Reagent is extremely powerful for gene functional studies and RNA interference in vivo. This reagent was made by our proprietary formula whichinteracts with nucleic acids, and move into cells via endocytosis. In addition to efficientlytransporting nucleic acidsinto the cells, the formula is also able to lead to the protection of the nucleic acids from lysosomal degradation andthe efficient release of those nucleic acidsfrom lysosomes to ensure maximum function. Avalanche^®-in vivo has been proven to be able to perform the maximum delivery of DNA, shRNA, siRNA, or oligonucleotides into different organs in the body. No significant pro-inflammatory responses have been detected using this reagent. Avalanche^®-in vivo can be administered via various routes, such as intravenous, intraperitoneal, intratumoral injection, etc. Avalanche^®-in vivo Transfection Reagent is the best choice for delivering nucleic acids in vivo.

References:

1. Baghel KS, Tewari BN, Shrivastava R, Malik SA, Lone MU, et al. Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1β dependent upregulation of MYO3A gene in breast cancer cells. Oncoimmunology. 2016 Jul 15;5(7):e1196299. PubMed PMID: 27622050; PubMed Central PMCID: PMC5006911.
2. Shimoda H, Doi S, Nakashima A, Sasaki K, Doi T, Masaki T. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a. Kidney Int. 2019 Nov;96(5):1162-1175. doi: 10.1016/j.kint.2019.06.021. Epub 2019 Aug 1. PubMed PMID: 31570196.

Features:

• Efficient delivery of DNA, shRNA, siRNA or oligonucleotides in vivo
• 200 µl reagent for 20 transfections in mouse
• Efficient delivery to the lung, liver, kidney, and spleen, liver, pancreas and certain type of tumor via systemic administration
• Delivery via Multiple modes of administration in many species
• Avalanche^®-in vivo/nucleic acid conjugated complexes are stable in serum for 16h
• No detectable inflammatory responses
• Efficient siRNA and plasmid DNA delivery via direct subcutaneous tumor injection (multiple tumor types)
• Reproducible results
• Applicable for plasmid DNA/siRNA co-injection
• Developed and manufactured by EZ Biosystems LLC